a tool for identifying drug-targetable redox-active disulphides

Protegrin-2

Intramolecular

Cysteine 136 and cysteine 145

A redox-regulated disulphide may form within Protegrin-2 between cysteines 136 and 145 (6 and 15 respectively in this structure).

Details

Redox score ?

89

PDB code

Structure name

high-resolution nmr structure of the protegrin-2 docked to dpc micelles

Structure deposition date

2014-09-10

Thiol separation (Å)

2

Half-sphere exposure sum ?

22

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

136

Residue number B

145

Peptide name

Protegrin-2

Ligandability

Cysteine 136 of Protegrin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of Protegrin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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